PPID is considered a slowly progressive disorder. The researchers noted that pergolide is recommended as a life-long daily treatment for equids with PPID.
Medical management of hyperinsulinemia with SGLT2 inhibitors is indicated for some horses, but it should be combined with appropriate management changes.
Many horses have mild signs of laminitis before they become lame, particularly at-risk horses such as seniors, ponies, and equids with insulin dysregulation.